The results from a clinical trial conducted at Fiona Stanley Hospital have been published in Science Translational Medicine.
In this study, a cream containing a drug called PXS-6302 was tested and found to safely change important aspects of scar tissue in adults with scars over a year old. In this trial, participants applied PXS-6302 cream to their scars three times a week for three months. The main result was a significant drop in an enzyme that helps make scars strong and dense, along with a reduction in collagen and total protein, the two most important building blocks of scar tissue.
Notably, the study also showed that the treated scars developed more small blood vessels. It started to look and behave more like healthy, normal skin under the microscope, even if there wasn’t a clear improvement in visible scar appearance within the short 3-month window. Importantly, PXS-6302 was well-tolerated, with no severe side effects and only mild, temporary skin reactions in some participants, suggesting this cream could become a simple, safe way to help remodel long-standing scars from the inside out.
The authors would like to thank everyone who volunteered their time to be part of this study and Syntara LTD.
For access to the article, please click here.
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